Thursday, Aug 06, 2020 | Last Update : 07:00 PM IST

135th Day Of Lockdown

Maharashtra46826530552116476 Tamil Nadu2734602148154461 Andhra Pradesh1864611043541681 Karnataka151449746792804 Delhi1402321261164044 Uttar Pradesh104388605581857 West Bengal83800589621846 Telangana7095850814576 Gujarat65704485612529 Bihar6203140760349 Assam4816233429115 Rajasthan4667932832732 Haryana3779631226448 Odisha3768124483258 Madhya Pradesh3508225414912 Kerala279561629988 Jammu and Kashmir2239614856417 Punjab1901512491462 Jharkhand140705199129 Chhatisgarh10109761369 Uttarakhand8008484795 Goa7075511460 Tripura5520367528 Puducherry4147253758 Manipur301818147 Himachal Pradesh2879171013 Nagaland24056594 Arunachal Pradesh179011053 Chandigarh120671520 Meghalaya9173305 Sikkim7832971 Mizoram5022820
  Life   Health  09 Apr 2019  Underwater forest treasure trove of potential drugs

Underwater forest treasure trove of potential drugs

Published : Apr 9, 2019, 3:10 pm IST
Updated : Apr 9, 2019, 3:10 pm IST

Studies show that underwater forest is a rich store of potential new drugs.

Extracts from Actinobacteria were screened for antimicrobial and anticancer activity. (Photo: Representational/Pexels)
 Extracts from Actinobacteria were screened for antimicrobial and anticancer activity. (Photo: Representational/Pexels)

Washington: For the first time, a new study has revealed that a common species of seaweed, Laminaria Ochroleuca, is a rich source of bacteria with antimicrobial and anticancer activities - and potential new drug candidates. The research was published in Frontiers in Microbiology.

Almost a century since Fleming discovered penicillin in a stray mould, scientists continue to look to microbes for new antibiotics and other medicines. To date, none has given more generously than the Actinobacteria: a family of soil- and seabed- dwelling bacteria who think they're fungi.


"About half of the 20,000+ microbe-derived drug candidates currently known come from Actinobacteria," said senior study author Dr Maria de Fátima Carvalho. "Now the supply of new species on land - where they form spores and branched networks just like a fungus - is beginning to run out," added Carvalho.

But relatively underexplored marine Actinobacteria may yet prove an even richer source of bioactive microbial molecules. "Several novel drug leads derived from marine Actinobacteria are already known.

These include anticancer agent salinosporamide A, currently in clinical trials, and several new antibiotics that are effective against drug-resistant infections like MRSA and tuberculosis," said Carvalho.


Predominantly found in sediments on the seafloor, Actinobacteria can also live inside other organisms that live and feed there - including brown algae (seaweed). "The brown alga Laminaria ochroleuca forms complex structures called kelp forests, which are among the most diverse and productive ecosystems in the world. But until now, no-one had characterised the Actinobacteria that live inside L. ochroleuca," said Carvalho.

In other kelp species, Actinobacteria are known to provide protective compounds in exchange for nutrients and shelter, which could be a source of new drug candidates.

Carvalho's team analysed a sample of L. ochroleuca from a rocky shore off northern Portugal. "After six weeks of culture in the lab, we isolated 90 Actinobacterial strains from the sample," said, Carvalho.


Extracts from these Actinobacteria were then screened for antimicrobial and anticancer activity. "Forty-five of the Actinobacterial extracts inhibited the growth of Candida albicans, Staphylococcus aureus, or both."

Some extracts were active against these common pathogens even at extremely low concentrations, making them promising candidates for the discovery of antimicrobial drugs. Several also showed selective anticancer activity.

Seven of the extracts inhibited the growth of breast and particularly nerve cell cancers while having no effect on non-cancer cells. "This study reveals that the seaweed L. ochroleuca is a rich source of Actinobacteria with promising antimicrobial and anticancer activities," said Carvalho. Further tests on the most potent of these strains revealed that some of the effects are likely the result of newly discovered compounds.


"We identified extracts from two Actinobacteria strains that do not match any known compounds in the most comprehensive international database of natural bioactive compounds. We intend to follow up on these exciting results," added Carvalho.

Tags: underwater forest, potential drug, bioactive compounds