Sunday, Aug 09, 2020 | Last Update : 08:10 PM IST

138th Day Of Lockdown

Maharashtra49026232728117092 Tamil Nadu2850242275754690 Andhra Pradesh2170401296151939 Karnataka164924842322998 Delhi1441271293624098 Uttar Pradesh118038698332028 West Bengal89666630601954 Telangana7751354330615 Bihar7578648673419 Gujarat68855517922604 Assam5549737225132 Rajasthan5065636310776 Odisha4419328698307 Haryana4005433444467 Madhya Pradesh3729827621962 Kerala3312020862107 Jammu and Kashmir2439020862459 Punjab2193014040539 Jharkhand165427503154 Chhatisgarh11408831987 Uttarakhand89015731112 Goa7947559570 Tripura6014408437 Puducherry5123291475 Manipur3635192711 Himachal Pradesh3242201513 Nagaland26888937 Arunachal Pradesh204913263 Chandigarh137482023 Meghalaya10234236 Sikkim8544061 Mizoram5672890
  Science   13 Jun 2020  In asymptomatic patients, the virus could be silently damaging their bodies

In asymptomatic patients, the virus could be silently damaging their bodies

Published : Jun 13, 2020, 3:00 pm IST
Updated : Jun 13, 2020, 3:00 pm IST

Up to 45 per cent of coronavirus infections may be asymptomatic, a new study reveals

A security officer stands guard outside the Xinfadi wholesale food market district in Beijing. (AP)
 A security officer stands guard outside the Xinfadi wholesale food market district in Beijing. (AP)

Los Angeles: As much as 45 per cent of people infected by the novel coronavirus behind the ongoing COVID-19 pandemic never show symptoms of the disease, according to a review of studies which suggests that the virus may silently damage the bodies of these asymptotic individuals.

Scientists, including Eric Topol from the Scripps Research Translational Institute in the US, analysed public datasets on asymptomatic infections of the novel coronavirus, SARS-CoV-2.


The findings, published in the journal Annals of Internal Medicine, suggested that asymptomatic people may account for approximately 40 to 45 per cent of SARS-CoV-2 infections, playing a significant role in the spread of the disease.

Based on the study, the scientists highlighted the need for expansive testing and contact tracing of infected individuals to mitigate the pandemic.

"The silent spread of the virus makes it all the more challenging to control," said Topol, founder and director of the Scripps Research Translational Institute and professor of Molecular Medicine at Scripps Research.

"Our review really highlights the importance of testing. It's clear that with such a high asymptomatic rate, we need to cast a very wide net, otherwise the virus will continue to evade us," he added.


In the study, Topol and his team collected information from testing studies on 16 diverse cohorts from around the world.

The scientists noted in a statement that these datasets were gathered via keyword searches of PubMed, bioRxiv and medRxiv, as well as Google searches of relevant news reports.

They said the analysis included data on nursing home residents, cruise ship passengers, prison inmates and various other groups.

"What virtually all of them had in common was that a very large proportion of infected individuals had no symptoms," said Daniel Oran, another co-author of the study.

"Among more than 3,000 prison inmates in four states who tested positive for the coronavirus, the figure was astronomical -- 96 percent asymptomatic," Oran said.


According to the review research, asymptomatic individuals are able to transmit the virus for an extended period of time, perhaps longer than 14 days.

The scientists noted that the viral loads are very similar in people with or without symptoms, but it remains unclear whether their infectiousness is of the same magnitude.

To resolve that issue, they said, large-scale studies that include sufficient numbers of asymptomatic people are needed.

The absence of symptoms may not imply an absence of harm, the researchers concluded.

Citing an example, they said CT scans conducted on asymptomatic individuals on the Diamond Princess cruise ship, appeared to show significant lung abnormalities, raising the possibility of the virus silently impacting lung function.


"Although the latter infected persons reported no symptoms, some actually had subclinical changes in their lungs. When computed tomography scans for 76 of these persons were examined, 54 per cent showed lung opacities," the researchers wrote in the study.

The scientists believe that further research is needed to confirm the potential significance of this finding.

They said the lack of longitudinal data makes distinguishing between asymptomatic and presymptomatic individuals difficult.

An asymptomatic individual, the researchers said, is someone who is infected with SARS-CoV-2, but never develops symptoms of COVID-19, while a presymptomatic person is similarly infected, but will eventually develop symptoms.


According to the scientists, longitudinal testing, which refers to repeated testing of individuals over time, would help differentiate between the two.

"Our estimate of 40 to 45 percent asymptomatic means that, if you're unlucky enough to get infected, the probability is almost a flip of a coin on whether you're going to have symptoms," Oran said.

"So to protect others, we think that wearing a mask makes a lot of sense," he concluded.

Tags: coronavirus study, covid-19, asymptomatic patients, details