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  Newsmakers   An anti-ageing coenzyme found

An anti-ageing coenzyme found

PTI
Published : Oct 16, 2016, 2:23 am IST
Updated : Oct 16, 2016, 2:23 am IST

Scientists have identified a compound that may delay physical ageing processes and prevent such as Alzheimer’s and Parkinson’s disease.

15AGE2.jpg
 15AGE2.jpg

Scientists have identified a compound that may delay physical ageing processes and prevent such as Alzheimer’s and Parkinson’s disease.

As we live longer and longer, a lot of people are occupied with their state of health and, not least, quality of life in old age.

 

Researchers all over the world are trying to understand ageing mechanisms, as it may eventually help postpone physical ageing and extend life. None of the existing explanations of physical ageing are able to explain all the biological aspects of human ageing.

Previous research showed that a main process in ageing is the capacity of the cells to keep our genes and DNA, more or less intact. However, changes in the cells’ power stations, the mitochondria, also affect ageing processes.

Researchers from the University of Copenhagen and the National Institute of Health, US have shown that the coenzyme NAD+ bridges the gap between two main ageing theories — repairs to the DNA and poor functioning mitochondria. “Our new study shows an age-dependent decrease in the level of NAD+, and this decrease is far greater for organisms with early ageing and a lack of DNA repairs,” said Vilhelm Bohr from the National Institute of Health. “We were surprised to see that adding NAD+ postponed both the ageing processes of the cells and extended life in worms and in a mouse model,” said Bohr.

 

The researchers bred mice and roundworm with the illness Ataxia telangiectasia (A-T) for the purpose of the study. In A-T patients the part of the brain that is responsible for coordination gradually degenerates, DNA repairs are lacking, and they experience other symptoms characteristic of early ageing.

“We know from previous studies that a drop in the level of NAD+ results in metabolism errors, neurodegeneration and ageing, but the underlying mechanisms remain unclear to us,” said Bohr. “Our new study stresses that the substance NAD+ plays a main role, both in maintaining the health of the cells’ power stations and in their capacity for repairing the genes,” he said.

 

Location: United States, Washington