Thursday, Aug 06, 2020 | Last Update : 06:49 AM IST

135th Day Of Lockdown

Maharashtra46826530552116476 Tamil Nadu2734602148154461 Andhra Pradesh1864611043541681 Karnataka151449746792804 Delhi1402321261164044 Uttar Pradesh104388605581857 West Bengal83800589621846 Telangana7095850814576 Gujarat65704485612529 Bihar6203140760349 Assam4816233429115 Rajasthan4667932832732 Haryana3779631226448 Odisha3768124483258 Madhya Pradesh3508225414912 Kerala279561629988 Jammu and Kashmir2239614856417 Punjab1901512491462 Jharkhand140705199129 Chhatisgarh10109761369 Uttarakhand8008484795 Goa7075511460 Tripura5520367528 Puducherry4147253758 Manipur301818147 Himachal Pradesh2879171013 Nagaland24056594 Arunachal Pradesh179011053 Chandigarh120671520 Meghalaya9173305 Sikkim7832971 Mizoram5022820
  Science   25 Jan 2020  First successful treatment for pain using stem cells discovered

First successful treatment for pain using stem cells discovered

THE ASIAN AGE
Published : Jan 25, 2020, 9:13 am IST
Updated : Jan 25, 2020, 9:13 am IST

The next step for the researchers is to perform extensive safety tests in rodents.

It could be a major breakthrough in the development of new non-opioid, non-addictive pain management strategies for patients.
 It could be a major breakthrough in the development of new non-opioid, non-addictive pain management strategies for patients.

In a breakthrough study on mice, researchers have used human stem cells to make pain-killing neurons, without side effects, in a single treatment.

The study was published in the journal Pain.

 

The next step for the researchers is to perform extensive safety tests in rodents and pigs and then move to human patients suffering chronic pain within the next five years.

If the tests are successful in humans, it could be a major breakthrough in the development of new non-opioid, non-addictive pain management strategies for patients, the researchers said.

"We are already moving towards testing in humans," said Associate Professor Greg Neely, a leader in pain research at the Charles Perkins Centre and the School of Life and Environmental Sciences.

"Nerve injury can lead to devastating neuropathic pain and for the majority of patients, there are no effective therapies. This breakthrough means for some of these patients, we could make pain-killing transplants from their own cells, and the cells can then reverse the underlying cause of pain."

 

The team used human induced pluripotent stem cells (iPSC) derived from bone marrow to make pain-killing cells in the lab, then put them into the spinal cord of mice with serious neuropathic pain. The development of iPSC won a Nobel Prize in 2012.

"Remarkably, the stem-cell neurons promoted lasting pain relief without side effects," co-senior author Dr Leslie Caron said. "It means transplant therapy could be an effective and long-lasting treatment for neuropathic pain. It is very exciting."

John Manion, a PhD student and lead author of the paper said: "Because we can pick where we put our pain-killing neurons, we can target only the parts of the body that are in pain. This means our approach can have fewer side effects."

 

The stem cells used were derived from adult blood samples.

The total cost of chronic pain in Australia in 2018 was estimated to be USD139.3 billion.

Tags: pain, study, research, stem cells